MD Courses — Cell Biology and Physiology

First year

M75 503 CELL AND ORGAN SYSTEMS BIOLOGY
Instructor: Robert W. Mercer, PhD, 362-6924
This course integrates and extends the basic principles of cell biology and physiology to the functions of the major organ systems of the body: muscle, cardiovascular, renal, respiratory, gastrointestinal and endocrine. Limited space is available for nonmedical students with instructor’s permission. This course is cross-listed in the Department of Neuroscience.

Selectives

M04 537 SIMULATIONS IN CARDIOVASCULAR PHYSIOLOGY
Instructors: David Murray, MD, 747-2136; Robert Moore, MD, 747-2136
The purpose of this selective is to demonstrate and explore cardiovascular physiology and cardiovascular control mechanisms using high fidelity, full-size electromechanical mannequins. By simulating events such as arrhythmias, hemorrhage, myocardial infarction and heart failure, students will explore how altering chronotropism, preload, afterload and contractility lead to changes in blood pressure, heart rate, central venous pressures and cardiac output. The course includes five interactive simulation laboratory sessions. During these sessions at the Howard and Joyce Wood Simulation Center, simulations will be used to demonstrate how ECG, arterial, venous, ventricular and pulmonary capillary wedge pressures, cardiac output, stroke volume, heart rate, systemic and pulmonary vascular resistance are measured and monitored in clinical practice. In these small-group sessions, students will explore how alterations in chronotropism, preload, inotropism and afterload lead to a variety of cardiovascular events. The sessions will also be used to demonstrate a variety of the cardiovascular control mechanisms such as the Frank-Starling response and baroreceptor-mediated reflex responses.

M04 596 ION CHANNELS AND DISEASE

Instructor: Colin G. Nichols, PhD, 362-6630
Ion channels are present in all cells and direct intracellular events by controlling the membrane electrical activity. Many widely used clinical drugs act by altering the behavior of ion channels, including epilepsy, diabetes, cardiac arrhythmias and cystic fibrosis. We will consider the basis of ion channel diseases and ion channel modulation therapies. Students will research a topic of choice in the library over two to three weeks and then present their findings to the whole class. After the initial course meeting, we will not meet formally for three weeks, and will then meet once per week for presentations.

Fourth year

Electives

Descriptions of the following courses may be found under Division of Biology and Biomedical Sciences.

L41 (Bio) 5062 CENTRAL QUESTIONS IN CELL BIOLOGY
L41 (Bio) 5068 FUNDAMENTALS OF MOLECULAR CELL BIOLOGY
L41 (Bio) 5122 CELL-MATRIX INTERACTIONS
L41 (Bio) 5132 CELL MOTILITY AND CYTOSKELETON JOURNAL CLUB

Note — The number preceding the course title indicates that the course carries credit in the Graduate School of Arts & Sciences. See course descriptions in the Graduate Programs section of this catalog.