Research — Neurosurgery

Michael R. Chicoine, MD
314-747-6143
Outcomes analysis for adult patients with brain tumors. Current clinical studies focus on outcomes of patients with benign and malignant brain tumors utilizing a prospective brain tumor database. Particular emphasis includes the impact of intraoperative MRI (iMRI) upon outcomes for patients with brain tumors and other diseases. We are establishing a multicenter database pooling data from multiple iMRI centers in North America.

Ian G. Dorward, MD
314-747-6142
Research interests include outcomes analysis in spinal reconstruction surgery, including the impact of age, obesity, and other clinical variables on costs, complications, and patient satisfaction. Another area of interest is the evaluation of novel techniques in spinal deformity correction and minimally invasive spinal surgery. Additional work focuses on etiologic factors in spinal deformity, both in adolescents and adults.

Gavin P. Dunn, MD, PhD
314-747-6141
Studies focus on examination of molecular mechanisms in the endothelial cells and smooth muscle cells in the intracerebral microcirculation and the contribution of glial cells to their impairment after hypoxia/reoxygenation. In vitro techniques for studying isolated perfused microvessels are used to examine questions centered on endothelial smooth muscle and glial cell integration of cerebral blood flow responses.

Albert H. Kim, MD, PhD
314-747-6141
I have laboratory and clinical research interests in the cancer stem cell state and the genetics of glioblastoma using human tumor specimens.  I additionally have clinical projects examining patient outcomes for two common types of brain tumors, meningiomas and pituitary tumors.

Eric C. Leuthardt, MD
747-6146
Pursuing research in the areas of neuroprosthetics, brain computer interfaces (BCIs), and advanced imaging modalities.  These include opportunities in basic neurophysiology, engineering for BCIs and functional MRI imaging research for applications towards brain tumors.

David D. Limbrick, MD, PhD
314-454-4630
Clinical and translational research into newborn brain injuries, including post-hemorrhagic hydrocephalus. Main research areas include cerebrospinal fluid protein markers of disease, MRI diffusion tensor imaging, and prospective clinical trials. Also, multi-institutional clinical research opportunities exist for syringomyelia associated with Chiari I malformation.

T. S. Park, MD
314-454-2810
Outcome studies of selective dorsal rhizotomies for treatment of spastic cerebral palsy in children, and brachial plexus repair for birth injury are ongoing projects. Multicenter outcome study of  syringomyelia associated with Chiari l malformation in children.

Wilson Z. Ray, MD
314-362-3114
Clinical and translational research on peripheral nerve and spinal cord injuries.  Lab based opportunities for longer research electives investigating peripheral nerve regeneration and peripheral neuroprosthetics incorporating transient electronics.

Keith M. Rich, MD
314-747-6142
Research on neuronal and glioma cellular apoptosis after treatment with DNA-damaging agents. Techniques include growing human brain tumor cells in culture, bioassay for apoptosis with fluorescent staining, protein immunoblotting, and PCR.

Matthew Smyth, MD
314-454-4454
Clinical outcomes studies for pediatric epilepsy surgery and craniosynostosis surgery, basic and translational research in advanced clinical imaging, and translational research in the development of focal brain cooling devices for the treatment of epilepsy.

Neill M. Wright, MD
314-747-6144
Clinical outcomes studies focusing on the treatment and results of cervical spine surgery.  Several active research opportunities include the evaluation of novel surgical techniques for treatment of the atlantoaxial (C1-2) segment, the use of synthetic bone in cervical spine surgery, the relationship between cervical spondylosis and dizziness, and the critical evaluation of certain intra-operative techniques and surgical practices.

Gregory J. Zipfel, MD
314-747-6141
My NIH-funded research program involves both basic and clinical research efforts focused on two main conditions: 1) Cerebral amyloid angiopathy and its contribution to ischemic stroke, vascular dementia, and Alzheimer’s Disease; and 2) Vasospasm-induced delayed cerebral ischemia and long-term cognitive deficits following aneurysmal subarachnoid hemorrhage.  My work spans from basic experimental methods including cell culture and ex vivo vascular techniques to in vivo studies utilizing animal models of ischemic stroke and subarachnoid hemorrhage and live animal epifluorescent and confocal imaging to Phase I clinical trials in patients.