Biology and Biomedical Sciences Courses

The following graduate courses are offered by the Division of Biology and Biomedical Sciences, and they are available both to PhD and MD students who meet the prerequisites for the appropriate course. Those courses particularly relevant to a given department are cross-listed under the department in this Bulletin.

L41 (BIO) 501 THE HUMAN BODY: ANATOMY, EMBRYOLOGY, AND IMAGING
For full description, see Department of Anatomy and Neurobiology’s M05 501A Human Anatomy and Development.

L41 (BIO) 5011 ETHICS AND RESEARCH SCIENCE
Instructors: Staff, Division of Biology and Biomedical Sciences, 362-3365

Exploration of ethical issues which research scientists encounter in their professional activities. Topics will include, but are not limited to: student-mentor relationships, allegations of fraud, collaborators’ rights and responsibilities, conflicts of interest, confidentiality, publications. Case study and scenario presentations will provide focus for discussions. Prereq, open to DBBS graduate students engaged in research. Six 90 minute sessions. Credit: 1 unit.

L41 (BIO) 5014 BIOTECH INDUSTRY INNOVATORS
Instructor: Erwin H. Peters, PhD, 862-4867
The Basics of Bio-Entrepreneurship, investigates issues and choices that inventors / scientists encounter when they are considering the applications and commercialization of early stage scientific discoveries. This course is intended for anyone interested in working in the biotechnology, pharmaceutical, medical device, or life-sciences industries as a founder, scientist, entrepreneur, manager, consultant, or investor. It focuses, through case studies and lectures, on the issues and decision processes that researchers and their business partners typically face when considering how a discovery might best be moved from academia to successful commercialization. Credit: 3 units. Same as B63 MGT 500U.

L41 (BIO) 502 GENERAL PHYSIOLOGY
Instructor: Robert Mercer, PhD, 362-6924
This course applies the fundamental physiological mechanisms of cell biology to the functions of the major organ systems of the body, namely, the cardiovascular, renal, respiratory, gastrointestinal and endocrine systems. The course is intended primarily for first-year medical students. The Physiology and Microscopic Anatomy courses are closely coordinated within the same schedule. Course continues into the spring semester with a different schedule. Prerequisites: Bio 5061 or the equivalent and permission of course director. Credit: 6 units.

L41 (BIO) 5053 IMMUNOBIOLOGY I
Instructor: Takeshi Egawa, 314-747-2516
Immunobiology I and II are a series of two courses taught by the faculty members of the Immunology Program. These courses cover in-depth modern immunology and are based on Janeway’s Immunobiology 8th Edition textbook. In Immunobiology I, the topics include: basic concepts in immunology, innate immunity: the first lines of defense, the induce responses of innate immunity, antigen recognition by B-cell and T-cell receptors, the generation of lymphocyte antigen receptors, antigen presentation to T lymphocytes and signaling through immune system receptors. In Immunobiogy II the topics include: the development and survival of lymphocytes, T cell-mediated immunity, the humoral immune response, dynamics of adaptive immunity, the mucosal immune system, failures of host defense mechanisms, allergy and allergic diseases, autoimmunity and transplantation, and manipulation of the immune response. These courses are open to graduate students. Advanced undergraduate students may take these courses upon permission of the coursemaster. Prerequisite: DBBS students and advanced undergraduates with permission. Credit 4 units.

L41 (BIO) 5054 IMMUNOBIOLOGY II
Instructor: Chyi-Song Hsieh, MD,PhD, 485-4485; Eugene Oltz, PhD, 362-5515
Immunobiology is a continuation of Immunobiology I (Bio 5053) taught by the faculty members of the Immunology Program and consists of two sections. In the first section, selected topics are covered in depth that were introduced in Immunobiology I. These include cytokine signaling, DC subsets, tumor immunology, evolution of the immune response, Fc Receptors, alloreactivity, mucosal immunity, inhibitory receptors, vaccines, lymphoorganogenesis and immunopathogenesis. The second section involves Molecular mechanisms of disease (formerly Bio 5261) and will cover human diseases that appear to have an immunological basis.  In addition to lectures and evaluation of recent clinical and relevant basic immunology literature, an emphasis will be placed on direct encounters with patients and pathologic material when feasible, providing students with a human aspect to discussions of immune pathogenesis.  Diseases covered will include rheumatoid arthritis, allergy, lupus, multiple sclerosis, diabetes, immunodeficiencies, complement diseases and hemophagocytic lymphohistiocytosis. Prereq: DBBS students and Immunobiology I. Credit: 4 units.

L41 (BIO) 5068 FUNDAMENTALS OF MOLECULAR CELL BIOLOGY
Instructor: Robert Mercer, PhD, 362-6924
This is a core course for incoming graduate students in Cell and Molecular Biology programs to learn about research and experimental strategies used to dissect molecular mechanisms that underlie cell structure and function, including techniques of protein biochemistry. Enrolling students should have backgrounds in cell biology and biochemistry, such as courses comparable to L41 BIO 334 and L41 BIO 4501. The format is two lectures and one small group discussion section per week. Discussion section focuses on original research articles. Same as M15 5068 and M04 5068. Same as E62 BME 5068. Credit: 4 units.

L41 (BIO) 5075 FUNDAMENTALS OF BIOSTATISTICS FOR GRADUATE STUDENTS
Instructor: Zachary Pincus, PhD, 747-5520
This course is designed for first-year DBBS students who have had little to no prior experience in programming or statistics. The course will cover common statistical practices and concepts in the life sciences, such as error bars, summary statistics, probability and distributions, and hypothesis testing. The class will also teach students basic programming skills for statistical computation, enabling them to retrieve and analyze small and large data sets from online databases and other sources. Credit:1 unit.

L41 (Bio) 5077 PHARMACEUTICAL RESEARCH AND DEVELOPMENT: CASE STUDIES
Instructor: Kinch, 262-9805
The course will provide an overview of the history of pharmaceutical research and development activities, with emphasis upon understanding a blend of the scientific, public health, regulatory and business decisions that have shaped the pharmaceutical industry over the past eight decades.  Particular emphasis will be placed on understanding how past trends have raised questions about the sustainability of the enterprise.  Although no prerequisites are formally requires, the course will blend basic understanding of scientific and medical terminology with an understanding of the commercial and policy decision-making processes that govern the pharmaceutical and biotechnology enterprises. Credit: 2 units.

L41 (BIO) 5084 MOLECULAR MOTORS AND SINGLE MOLECULE TECHNIQUES
Instructor: Michael Greenberg, PhD, 362-8670
Molecular motors in the cell harness chemical energy to generate mechanical work in a host of processes including cell motility, DNA replication and repair, cell division, transcriptional regulation, and intracellular transport. The purpose of this course is to discuss recent advances in the field of molecular motors. Special emphasis will be placed on understanding and criticially evaluating single molecule studies. The course will consist of both journal club presentations and small group discussions. Credit: 2 units.

L41 (BIO) 5123 EXPERIMENTAL HEMATOPOIESIS JOURNAL CLUB
Instructor: Daniel C. Link, MD, 362-8771
Journal club in which papers that describe significant advances in the field of experimental hematopoiesis are discussed. Students are expected to present one paper per semester and attend the weekly (1 hour) session. No prerequisites. Credit: 1 unit.

L41 (BIO) 5128 CELL BIOLOGY OF EXTRACELLULAR MATRIX JOURNAL CLUB
Instructor: Jeff Miner, PhD, 362-8235
This journal club covers a broad range of topics current interest, including the fields of biochemistry, molecular biology, cell biology and developmental biology. Speakers give a brief background to introduce the topic and then focus on one-two papers from the current literature. Presentations are given by students, faculty and postdoctorates. Students receive one credit for regular participation and for making one presentation. Credit: 1 unit.

L41 (BIO) 5137 ION CHANNELS JOURNAL CLUB
Instructor: Colin G. Nichols, PhD, 362-6630
Weekly presentations of recent papers on mechanisms of ion channel function and membrane excitability, as well as the role of channel defects in human and model diseases, with lively group discussions the norm! Once per semester, each participant will choose a paper and present it to the group. Credit: 1 unit.

L41 (BIO) 5138 JOURNAL CLUB FOR THE MOLECULAR MECHANISM OF AGING
Instructor: Shin-ichiro Imai, MD, PhD, 362-7228
Why do we age? What causes aging? How is our life span determined? This journal club will address such fundamental but challenging questions of aging and longevity. Recent studies on aging and longevity are now unveiling regulatory mechanisms of the complex biological phenomenon. We’ll cover the latest progress in this exciting field and stimulate discussions on a variety of topics including aging-related diseases. One hour of paper presentation or research talk and discussion per every two weeks. Prerequisite: Basic knowledge of molecular biology and genetics of model organisms, such as yeast, C. elegans, Drosophila and mouse. Registered students are expected to have at least one presentation for 1 unit credit. Credit: 1 unit.

L41 (BIO) 5139 SEMINAR IN IMAGING SCIENCE AND ENGINEERING
Instructor: Joseph O’Sullivan, PhD, 935-4173
This seminar course consists of a series of tutorial lectures on Imaging Science and Engineering with emphasis on applications of imaging technology. Students are exposed to a variety of imaging applications that vary depending on the semester, but may include multispectral remote sensing, astronomical imaging, microscopic imaging, ultrasound imaging and tomographic imaging. Guest lecturers come from several parts of the university. This course is required of all students in the Imaging Science and Engineering program; the only requirement is attendance. This course is graded Pass/Fail. Prerequisite: Admission to Imaging Science and Engineering Program. Same as E35 ESE 596. Credit: 1

L41 (BIO) 5146 PRINCIPLES AND APPLICATIONS OF BIOLOGICAL IMAGING
Instructors: Adam Bauer, 362-6942; David Reichert, PhD, 362-9940, Joshua Shimony, PhD, 362-5950
Principles and Applications of Biological Imaging will introduce the interdisciplinary nature of the imaging sciences and conduct a comprehensive survey of the array of interrelated topics that define biological imaging. The course will cover the basics of the optical, magnetic resonance, CT, SPECT and PET imaging modalities, and microscopy, while focusing on applications of imaging to different disease states, such as oncology, neurology, cardiology and pulmonary diseases. Prereqs. One year each of Biology, Chemistry, Physics and Calculus. Credit: 3 units.

L41 (BIO) 5148 METABOLISM JOURNAL CLUB
Instructors: Daniel Ory, MD, 362-8737, Jean Schaffer, MD, 362-8717
The purpose of the Metabolism Journal Club is to introduce the graduate students to advanced topics spanning the biochemistry, cell biology and genetics of cellular and whole body metabolism. Under the guidance of the course directors (Drs. Ory and Schaffer), students will select recent topical articles for discussion in the weekly journal club. Students will be expected to provide a succinct introduction to the topic and lead discussion of the data presented in the journal article. Students will be evaluated on the basis of their presentation and their participation in the seminar throughout the semester. Prereqs: Successful completion of Fundamentals of Molecular Cell Biology (Bio 5068) and Nucleic Acids and Protein Biosynthesis (Bio 548). Credit: 1 unit.

L41 (BIO) 5151 RNA BIOLOGY JOURNAL CLUB
Instructors: Daniel Ory, MD, 362-8737, Jean Schaffer, MD, 362-8717
The purpose of the RNA Biology Journal Club is to introduce the graduate students to advanced topics spanning the bioinformatics, biochemistry, cell biology and genetics of RNA biology. Under the guidance of the course directors (Drs. Ory and Schaffer), students will select recent topical articles for discussion in the weekly journal club. Students will be expected to provide a succinct introduction to the topic and lead discussion of the data presented in the journal article. Students will be evaluated on the basis of their presentation and their participation in the seminar throughout the semester. Prerequisites: Successful completion of Fundamentals of Molecular Cell Biology (Bio 5068) and Nucleic Acids and Protein Biosynthesis (Bio 548) or permission of instructors. Credit: 1 unit.

L41 (BIO) 5152 DEVELOPMENT, REGENERATION AND STEM CELL BIOLOGY JOURNAL CLUB
Instructor: Craig Micchelli, PhD, 362-7036
Focuses on developing a dialog around current topics in developmental and regenerative biology at the molecular, cellular and systems levels. Credit: 1 unit.

L41 (BIO) 5171 MEDICAL IMMUNOLOGY
Instructor: Andrey S. Shaw, MD, 362-4614
An introduction to basic concepts in immunology and immunopathology. Lectures focus on antigen-antibody interactions, immunoglobulin structure and genetics, the cellular basis of the immune response and immune regulation, T cell effector mechanisms, the inflammatory response, complement, the positive and negative roles of hypersensitivity, and immune deficiency. Prerequisite: some background in biochemistry and genetics helpful. Restricted to medical students only except in unusual circumstances, with permission of coursemaster. Offered during the first half of the second medical semester. Three-four lecture hours a week, two (2) two-hour lab periods, four (4) one-hour clinical discussion groups. Credit: variable, maximum 3 units.

L41 (BIO) 5191 PATHOBIOLOGY OF HUMAN DISEASE STATES
Instructors: Audrey Odom, MD, PhD, 747-2370; Thomas Fehniger, MD, PhD, 747-1385
Three human disease states will be discussed in detail. Topics will include background clinical and epidemiological information, followed by a detailed examination of the molecular and cellular events that underlie the disease state. Examples of pertinent topics include Alzheimer’s disease, AIDS, leukemia, cystic fibrosis, sickle cell anemia, diabetes, etc. Prerequisite: Must be a Markey Pathway student and have HIPAA training. Credit: 2 units.

L41 (BIO) 5192 CANCER BIOLOGY JOURNAL CLUB
Instructor: Ron Bose, PhD, 747-9308
This journal club covers current papers in molecular oncology, cancer genetics and contemporary molecular biology. Presentations will be given by students, post-docs and faculty, then discussed. Credit: 1 unit.

L41 (BIO) 5196 SPECIAL EMPHASIS PATHWAY IN CANCER BIOLOGY
Instructor: David Wilson, MD, PhD, 286-2834
This course is designed to present pre- and postdoctoral trainees with an organized educational format to explore major contemporary topics in cancer biology. The elective will provide an integrated view of cancer research including basic science, translational science, and clinical investigation. Approximately 60 minutes will be devoted to a didactic presentation by a faculty member with interaction by the participants. The remaining 30 minutes will be used to discuss a pivotal research paper from this field, preselected by the faculty member. Outside reading (30-60 min/week) will be required. Credit: 2 unit.

L41 (BIO) 5217 SPECIAL TOPICS IN MICROBIAL PATHOGENESIS
Instructors: Michael Caparon, PhD, 362-1485, Tamara Doering, MD, PhD, 747-5597, Amanda Lewis, MD, PhD, 286-0016
Primarily for graduate and MSTP students, this course is centered on critical evaluation of current scientific literature, which is used as a basis for discussion and grant writing, supplemented with sessions on experimental methodology. Paper discussions will involve oral presentation and discussion of current research articles on pathogenic microorganisms (bacteria, fungi, parasites, and viruses) and the cellular and molecular basis of host-pathogen interactions. Emphasis will be placed on understanding methods, critical evaluation of data, and design of future experiments for the articles covered. Students are expected to prepare all articles, to participate actively in all discussions, and to lead one or more discussions during the semester. The grant writing aspect of the course will focus on defining identifying key unanswered questions from the literature, formulating hypotheses for testing, defining Specific Aims, and developing a research plan. Students will submit specific aims based on current literature, receive critiques from faculty members, and develop a NIH-style proposal to investigate them. Students will participate in class discussions and a mock study section to evaluate proposals. Prereq, completion of the MMMP advanced elective, Bio 5392 Molecular Microbiology & Pathogenesis or permission of the coursemaster. Class meets twice per week for 1.5 hours each. Credit 2 units.

L41 (BIO) 5224 MOLECULAR, CELL AND ORGAN SYSTEMS
Instructor: Kendall Blumer, PhD, 362-1668
This course will introduce PhD and MSTP students to fundamental problems in cell and molecular biology at the systems level. The course is divided into five themes: 1) microbial systems; 2) organ development and repair; 3) cardiovascular system and disease; 4) tumor and host systems; and 5) metabolic systems and disease. Topics within each theme highlight current research concepts, questions, approaches and findings at the molecular, cellular and physiological levels. Students will write an original research grant proposal on a topic of their choosing in one of the five themes. Students will critique proposals anonymously in an NIH-like study section. Prerequisites: Fundamentals of Molecular Cell Biology and Nucleic Acids and Protein Synthesis. Credit: 3 units.

L41 (BIO) 5235 GENETICS JOURNAL CLUB
Instructor: Heather Lawson, PhD, 362-7269
This journal club will be focused on the Genetics Department seminar series. Students will present one or a few recent papers by the seminar speaker scheduled for that week. Students will provide a brief written evaluation (on a form that will be provided) of their peers’ presentations, and the faculty advisors will meet with each student after the presentation to provide feedback. Credit: 1 unit.

L41 (BIO) 5255 EXPERIMENTAL SKELETAL BIOLOGY JOURNAL CLUB
Instructor: Steven Teitelbaum, MD, 454-8463
The journal club, which meets weekly, focuses on cellular and molecular biology of the skeleton. Emphasis is placed on gaining insights into normal skeletal homeostasis as well as systemic disorders of bone. Papers presented for review are selected from the most competitive journals. Participants are encouraged to “think outside of the box” and discuss novel molecular discoveries that may impact bone cell function. Prerequisite: Permission of instructor. Credit: 1 unit.

L41 (BIO) 5272 ADVANCED TOPICS IN IMMUNOLOGY
Instructors: Paul Allen, PhD, 362-8758; Eugene Oltz, PhD, 362-5515
This course uses a journal club format to discuss contemporary issues in the cell and molecular biology of the immune system. Discussions focus on the use of current approaches to analyze the cellular and molecular basis of immunity. Topics include mechanisms of antigenic specificity, diversity, cell communication, differentiation, activation and effector activity. Prerequisite: L41 (Bio) 5051 and permission of instructor. Credit: 2 units. This is referenced in the Department of Pathology and Immunology.

L41 (BIO) 5284 CURRENT RESEARCH IN CHROMATIN, EPIGENETICS AND NUCLEAR ORGANIZATION
Instructors: Douglas L. Chalker, PhD, 935-8838; Sarah Elgin, PhD, 935-5348
This journal club considers papers from the current literature on chromatin structure and function, with an emphasis on regulation of transcription, epigenetics and genomics. Presentations are given by students, postdocs and faculty, with discussion by all. Students enrolled for credit are expected to attend regularly, and to present a minimum of one paper during the term, with consultation and critique from the faculty. Credit 1 unit.

L41 (BIO) 5285 FUNDAMENTALS OF MAMMALIAN GENETICS
Instructor: Patrick Jay, MD, PhD, 362-2174
This course aims to provide both biologists and those with mathematical backgrounds with a basis in mammalian genetics. The course will include the following modules: Nucleic acid biochemistry; Gene and chromosome organization; Intro to Human Genetics; Mutations and DNA repair; Cancer Genetics; Genomic methodologies; Biochemical genetics; Murine Genetics; Epigenetics; Neurodegenerative diseases; Mitochondrial disorders; Pharmacogenetics; Intro to human population genetics; Applications of modern human genetics; Intro to web-based informatics tools for molecular genetics. One of the required courses in the Quantitative Human Statistical Genetics graduate program. Credit: 3 units.

L41 (BIO) 5303 PROTEIN NMR JOURNAL CLUB
Instructor:TBA-362-3364
This journal club covers the recent literature on protein NMR with a focus on using NMR to study protein function, NMR dynamics, and novel methods that expand the range of systems accessible to solution NMR studies. Students, postdocs and faculty discuss a recent paper and present background information on the relevant technical aspects of NMR. Students receive 1 credit for participation and presenting one paper. Credit: 1 unit.

L41 (BIO) 5311 DYNAMICS IN MESOSCOPIC MOLECULAR SYSTEMS
Instructor: Elliot Elson, PhD, 362-3346
This course will provide a background in the theory of the dynamics of mesoscopic systems and introduction to methods for measuring the dynamics of these systems. It will include measurement methods, some of which are in common use and others that have only recently been introduced. This course would be useful for biophysics students and others that are interested in molecular processes and mechanisms in small systems such as cells. Prerequisite: Physical Chemistry. Credit: 3 units.

L41 (BIO) 5312 MACROMOLECULAR INTERACTIONS
Instructor: Timothy M. Lohman, PhD, 362-4393
This course will cover equilibria, kinetics and mechanisms of macromolecular interactions from a quantitative perspective. Thermodynamics, multiple binding equilibria (binding polynomials), linkage phenomena, cooperativity, allostery, macromolecular assembly, enzyme catalysis and mechanism, steady-state and pre-steady state kinetics, and isotope effects. Modern methods of computer analysis using nonlinear least squares fitting and simulation to analyze binding isotherms and full kinetic time courses is emphasized. Prerequisite: Physical Chemistry, Biochemistry, Calculus and Organic Chemistry. Three class hours per week. Credit: 3 units.

L41 (BIO) 5314 MOLECULAR BIOPHYSICS GRADUATE SEMINAR
Instructor: Kathleen B. Hall, PhD, 362-4196
Student presentation of molecular biophysics topic. Second-year students present from literature; senior students give formal research seminar. Attendance required for all molecular biophysics students. Credit: 1 unit.

L41 (BIO) 5319 MOLECULAR FOUNDATIONS OF MEDICINE
Instructor: Linda J. Pike, PhD, 362-9502
This course will cover fundamental aspects of biochemistry and cell biology from a medical perspective. The course begins with a treatment of protein structure and the function of proteins in the cytoskeleton and cell motility. The principles of enzyme kinetics and regulation are then discussed and basic pathways for the synthesis and metabolism of carbohydrates and lipids are introduced. This leads in to a discussion of membrane structure and the function cellular organelles in biological processes including energy production, protein degradation and protein trafficking. Prereq: Two semesters of organic chemistry. Coursemaster approval is required.  Please note: This course is given on the medical school schedule and so it begins 8 days before the grad school schedule. Credit: 3 units.

L41 (BIO) 5328 STRUCTURAL BIOLOGY JOURNAL CLUB
Instructor: Thomas Brett, PhD, 747-0018
Multi-laboratory research colloquia for DBBS graduate students focused on structural biology and complementary biophysical techniques. Course credit requires student presentation for credit. Credit: 1 unit.

L41  5336  BIOLCOMPUTATIONAL BIOPHYSICS JOURNAL CLUB
Instructor: Gregory Bowman, PhD, 362-7433
This course covers a combination of classic and recent publications on computational methods for studying biomolecules. Students participating for credit will be required to present at least once. Credit: 1 unit.

L41 (BIO) 5352 DEVELOPMENTAL BIOLOGY
Instructor: Kerry Kornfeld, MD, PhD, 747-1480
Analysis of a selected set of key processes in development, such as pattern formation, cell-cell signaling, morphogenesis, etc. The focus is on molecular approaches applied to important model systems, but framed in classical concepts. The discussion section provides instruction in presenting a journal club and writing a research proposal. Prereqs, Molecular Cell Biology (Bio 5068) and Nucleic Acids (548). Credit: 3 units.

L41 (BIO) 5357 CHEMISTRY AND PHYSICS OF BIOMOLECULES
Instructor: Paul Schlesinger, MD, PhD, 362-2223
This course covers three major types of biomolecular structure: proteins, nucleic acids and membranes. Basic structural chemistry is presented, as well as biophysical techniques used to probe each type of structure. Selected topics include: protein folding, protein design, X-ray crystallography, NMR spectroscopy, nucleic acid bending and supercoiling, nucleic acid:protein interactions, RNA folding, membrane organization, fluidity, permeability and transport, and membrane channels. Weekly discussion section will cover problem sets and present current research papers. One of the required courses for the Biochemistry and for the Molecular Biophysics graduate programs. Prerequisites: prior coursework in Biochemistry and in Physical Chemistry is recommended, but not required. Credit: 3 units.

L41 (BIO) 5358 BIOCHEMICAL AND BIOPHYSICAL INVESTIGATIONS OF INFECTIOUS DISEASES JOURNAL CLUB
Instructor: Jeffrey Henderson, MD PhD, 747-0240
Biochemical and biophysical approaches continue to advance as powerful approaches to understand human disease processes. This journal club covers recent papers in which these approaches address aspects of infectious diseases or inflammation. Students enrolling for credit will be expected to participate in weekly presentations and to present 1-2 papers along with accompanying background. Prereqs:Graduate standing in DBBS; prior introductory coursework in biochemistry, physical chemistry, or Chemistry and Physics of Biomolecules (Bio 5357); courswork in microbiology or immunology is not required. Credit: 1 unit.

L41 (BIO) 5392 MOLECULAR MICROBIOLOGY AND PATHOGENESIS
Instructor: Joseph Vogel, PhD, 747-1029
Course is devoted to studying microorganisms, particularly those that cause disease, with an emphasis on the molecular interactions between pathogens and hosts. First third of the course focuses on virology, second third on bacteriology and the last third on eukaryotic pathogens. Prereq, first semester core curriculum for Programs in Cell and Molecular Biology. Credit: 3 units. This is referenced in the Department of Molecular Microbiology.

L41 (BIO) 5397 CURRENT LITERATURE IN MICROBIOLOGY
Instructor: David Sibley, PhD, 362-8839
Presentations by students on a broad range of topics of current interest in microbiology. The course will emphasize presentations and discussion skills. Credit requires attendance and participation at all sessions and one presentation. Credit 1 unit.

L41 (BIO) 5412 TROPICAL AND MOLECULAR PARASITOLOGY
Instructor: L. David Sibley, PhD, 362-8873
Graduate-level seminar course focusing on current scientific literature in molecular parasitology. The journal club will meet biweekly during the Fall and Spring semesters. Students will attend both semesters in order to receive one credit. The seminar series will run jointly with a research conference in Tropical and Molecular Parasitology. Outside speakers will be invited for the seminar series to emphasize important developments in tropical medicine and molecular parasitology. In advance of the invited speakers, topics will focus on their previous research publications. Prerequisite: L41 (BIO) 5392 Molecular Microbiology and Pathogenesis. Credit 0.5 unit.

L41 (BIO) 5417 HEMATOLOGY/ONCOLOGY JOURNAL CLUB
Instructor: Monita Wilson, PhD, 362-8839
This journal club covers a broad range of topics of current interest, including the fields of biochemistry, molecular biology, cell biology, developmental biology and immunology. Speakers usually give a brief background to introduce the topic and then focus on one or two papers from the current literature. Presentations are given by graduate students, post-doctorates and faculty. Each attendee presents two to three times per year. Participants are expected to attend all the sessions. This journal club was formed in 1966. Credit: 1 unit.

L41 (BIO) 5425 IMMUNOLOGY OF INFECTIOUS DISEASES JOURNAL CLUB
Instructor: Shabaana Khader, PhD, 286-1590
The goal of this Journal Club (JC) is to provide 2nd year students in MMMP program a platform to discuss new and emerging concepts on mechanisms by which host immune responses mediate protection against infectious diseases. This exercise will aslo enable the student who attend the fundatmental Immunology course to apply their knowledge to understand the basis for immunology of infectious diseases. The format will include faculty who will select cutting-edge papers and head the discussion during the JC session. Credit: 1 unit.

L41 (BIO) 5426 ID GATEWAY: TRANSLATIONAL AND PUBLIC HEALTH ASPECTS OF BASIC INFECTIOUS DISEASE RESEARCH
Instructors: S. Celeste Morley, MD,PhD, 286-2136; Robyn Klein, MD, PhD, 286-2140
This course provides an opportunity for students, postdoctoral fellows, infectious disease fellows and faculty to explore issues at the interface between patient care, public health and basic research in the area of microbial pathogenesis. Prerequisites: Application and L41 (BIO) 5392 or M30 526, or permission of instructor. Credit: 2 units.

L41 (BIO) 5445 DNA METABOLISM JOURNAL CLUB
Instructor: Roberto Galletto, PHD, 362-4368
Presentation of current research papers in DNA replication, DNA repair and DNA recombination, with an emphasis on basic biochemical and biophysical approaches. Credit: 1 unit.

L41 (BIO) 5466 CURRENT TOPICS IN BIOCHEMISTRY
Instructor: Kathleen B. Hall, PhD, 362-4196
Special topics course offered every other week involving the discussion of research papers covering a broad range of topics in the field of biochemistry. Papers selected from the primary literature will be presented and discussed by students with guidance from the instructor. Emphasis will be placed on papers that illustrate the application of chemical approaches to important biological processes. Designed primarily for first- and second-year graduate students in the Biochemistry Ph.D. program. Prereqs: coursemaster permission.  Credit: 0.5 unit.

L41 (BIO) 5468 CARDIOVASCULAR BIOPHYSICS JOURNAL CLUB
Instructor: Sándor J. Kovács, PhD, MD, 454-7660
This journal club is intended for beginning graduate students, advanced undergraduates and MSTP students with a background in the quantitative sciences (engineering, physics, math, chemistry, etc.). The subjects covered are inherently multidisciplinary. We will review landmark and recent publications in quantitative cardiovascular physiology, mathematical modeling of physiologic systems and related topics such as chaos theory and nonlinear dynamics of biological systems. Familiarity with calculus, differential equations and basic engineering/thermodynamic principles is assumed. Knowledge of anatomy/physiology is optional. Same as E72 BME 5911. Credit: 1 unit.

L41 (BIO) 548 NUCLEIC ACIDS AND PROTEIN BIOSYNTHESIS
Instructor: Eric Galburt, PhD, 362-5201
Fundamental aspects of structure, biosynthesis and function of nucleic acids and the biosynthesis of proteins. Emphasis on mechanisms involved in the biosynthetic processes and the regulation thereof. Prerequisite: L41 (Bio) 3371, 451, Chem 481 or equivalent or permission of instructor. This is referenced in the Department of Biochemistry and Molecular Biophysics. Credit: 3 units.

L41 (BIO) 5483 HUMAN LINKAGE AND ASSOCIATION ANALYSIS
Instructor: John P. Rice, PhD, 286-2572
Basic Genetic concepts: meiosis, inheritance, Hardy-Weinberg Equilibrium, Linkage, segregation analysis; Linkage analysis: definition, crossing over, map functions, phase, LOD scores, penetrance, phenocopies, liability classes, multi-point analysis, non-parametric analysis (sibpairs and pedigrees), quantitative trait analysis, determination of power for mendelian and complex trait analysis; Linkage Disequilibrium analyses: allelic association (case control designs and family bases studies), QQ and Manhattan plots, whole genome association analysis; population stratification; Quantitative Trait Analysis: measured genotypes and variance components. Hands-on computer lab experience doing parametric linkage analysis with the program LINKAGE, model free linkage analyses with Genehunter and Merlin, power computations with SLINK, quantitative trait anaylses with SOLAR, LD computations with Haploview and WGAViewer, and family-based and case-control association anaylses with PLINK and SAS. The methods and exercises are coordinated with the lectures and students are expected to understand underlying assumptions and limitations and the basic calculations performed by these computer programs. Auditors will not have access to the computer lab sessions. Prereq: M21-515 Fundamentals of Genetic Epidemiology. For details, to register and to receive the required permission of the Coursemaster contact the GEMS Program Manager (pa@wubios.wustl.edu or telephone 362-1052). Credit: 2 units. Same as M21 GEMS 5483.

L41 (BIO) 5484 GENETICS AND DEVELOPMENT OF C. ELEGANS JOURNAL CLUB
Instructor: Tim Schedl, PhD, 362-6162
Students will present a research paper (or present their current thesis research) and the appropriate background material. Credit: 1 unit.

L41 (BIO) 5487 GENETICS GENETICS AND GENOMICS OF DISEASE
Instructor: Tim Schedl, PhD, 362-6162, Christina Gurnett, MD, PhD, 286-2789, John Welch, MD, PhD, 362-2626
The course will cover the use of genomic and genetic information in the diagnosis and treatment of disease, with an emphasis on current practice and existing gaps to be filled to achieve precision medicine. Areas of discussion include: bioinformatics methods; assessment of pathogenicity; use and curation of disease variant databases; discovery of incidental findings; genomics applications in Mendelian disease, complex traits, cancer, pharmacogenomics, and infectious disease; design of clinical trials with genetic data; ethical and policy issues. Prerequisites: Genomics (Bio 5488), Advanced Genetics (Bio 5491), or Fundamentals of Mammalian Genetics (Bio 5285) or equivalent (permission from instructor). Credit: 2 unit.

L41 (BIO) 5488 GENOMICS
Instructors: Ting Wang, PhD, 286-0865; Donald Conrad, PhD, 362-4379
This course is designed for beginning students who want to become familiar with the basic concepts and applications of genomics. The course covers a wide range of topics including how genomes are mapped and sequenced as well as the latest computational and experimental techniques for predicting genes, splice sites, and promoter elements. High throughput techniques for ascribing function to DNA, RNA, and protein sequences including microarrays, mass spectrometry, interspecies genome comparisons and genome-wide knock-out collections will also be discussed. Finally, the use of genomic techniques and resources for studies of human disease will be discussed. A heavy emphasis will be put on students acquiring the basic skills needed to navigate databases that archive sequence data, expression data and other types of genome-wide data. Through problem sets the students will learn to manipulate and analyze the large data sets that accompany genomic analyses by writing simple computer scripts. While students will become sophisticated users of computational tools and databases, programming and the theory behind it are covered elsewhere, in Michael Brent’s class, Bio 5495 Computational Molecular Biology. Because of limited space in our teaching lab, enrollment for lab credit will be limited to 24 students. Priority will be given to students in the DBBS program. Others interested in the course may enroll for the lectures only. If you have previous experience in computer programming, we ask that you do not enroll for the laboratory credit. Prereqs, Molecular Cell Biology (Bio 5068), Nucleic Acids (Bio 548) or by permission of instructor. To enroll in just the lecture section, register for 3 credits. To enroll in both the lecture and lab sections, register for 4 credits. Credit: 3 or 4 units.

L41 (BIO) 5489 HUMAN GENETICS JOURNAL CLUB
Instructor: Nancy Saccone, PhD, 747-3263
In this biweekly journal club on Human Genetics we will present and discuss current cutting-edge papers in human and mammalian molecular genetics. Students learn presentation skills, how to critique a paper and how to interact with a very active and critical audience. Prerequisites: Any person interested in the current state of the art in Human Genetics may attend this course. It is a requirement that all students wishing to earn credit in this course must present a 1.5-hour journal club talk and must regularly attend and participate in the journal club throughout the year. Credit: 0.5 units

L41 (BIO) 5491 ADVANCED GENETICS
Instructor: Tim Schedl, PhD, 362-6162
Fundamental aspects of organismal genetics with emphasis on experimental studies that have contributed to the molecular analysis of complex biological problems. Examples drawn from bacteria, yeast, nematodes, fruit flies and mammalian systems. Prerequisite: graduate standing or permission of instructor. This is cross-listed in the Department of Genetics. Credit: 3 units.

L41(BIO)  5495 COMPUTATIONAL MOLECULAR BIOLOGY
Instructor: Michael Brent, PhD, 286-0210
This course is a survey of algorithms and mathematical methods in biological sequence analysis (with a strong emphasis on probabilistic methods) and systems biology. Sequence analysis topics include introduction to probability, probabilistic inference in missing data problems, hidden Markov models (HMMs), profile HMMs, sequence alignment, and identification of transcription-factor binding sites. Systems biology topics include discovery of gene regulatory networks, quantitative modeling of gene regulatory networks, synthetic biology, and (in some years) quantitative modeling of metabolism. Prereqs: CSE131 or CSE501N.  Same as home course E81 CSE 587A. Credit: 3 units.

L41 (BIO) 5496 SEMINAR IN COMPUTATIONAL MOLECULAR BIOLOGY
Instructor: Jeremy Buhler, PhD, 935-6180, Gary D. Stormo, PhD, 747-5534
Students present current research papers and the appropriate background material in the field of computational biology. **Arts and Sciences students must take this course for credit; Engineering students must take this course Pass/Fail.** Same as E81 CSE 7801. Credit: 1 unit.

L41 (BIO) 5499 CANCER INFORMATICS JOURNAL CLUB
Instructor: Obi Griffith, PhD, 747-9248.
This journal club will explore current topics in cancer informatics. Current literature will be reviewed for advanced cancer genome analysis methods, statistics, algorithms, tools, databases, and other informatics resources. Credit: 1 unit.

L41 (BIO) 550 MEDICAL GENETICS
Instructor: Susan Dutcher, PhD, 362-2765
A significant portion of the first-year course in basic medical genetics devoted to human and clinical genetics, with emphasis on how genomic information will transform the practice of medicine. Topics covered include population genetics, molecular basis of mutations; human functional genomics; mouse models of human disease; pharmacogenomics; metabolic defects. Lectures, small group discussions, patient information session. Prerequisite: an introductory genetics course and permission of the instructor. This is cross-listed in the Department of Genetics as M30 511 Medical Genetics. Credit: 2 units.

L41 (BIO) 5501 THE BIOLOGY AND PATHOLOGY OF THE VISUAL SYSTEM
Instructor: DidierHodzic, PhD, 362-7037
The purpose of the course is to provide a fascinating view of vertebrate eye development, anatomy, physiology and pathology. Topics to be covered include the molecules that control eye formation, ocular stem cells, the physiology of transparency, hereditary ocular diseases, phototransduction, the neurobiology of the retina and central visual pathways, age-related eye diseases, and many others. The course is open to all second year graduates students and above. Ophthalmology residents and postdocs with an interest in vision are strongly encouraged to attend. Credit: 3 units.

L41 (BIO) 5505 INDEPENDENT STUDY IN FUNDAMENTALS OF MOLECULAR AND MICROBIAL GENETICS
Instructor: James Skeath, PhD, 362-0535
This literature-based course will introduce students to seminal and current studies in molecular and microbial genetics.  Students will read and present a minimum of 12 landmark papers that helped shape our understanding of molecular and microbial genetics.  Emphasis will be placed on students’ ability to comprehend and explain these studies via chalk talks.  All presentations will be given by students. Prereqs: L41 5491 Advanced Genetics and permission from instructor. Credit: 2 units.

L41 (BIO) 5507 GENOME ENGINEERING METHODS AND APPLICATIONS
Instructor: Jeffery Milbrandt, MD, PhD, 362-4651.
This course will cover the basic principles of genome engineering with emphasis on Cas9/CRISPR technology.  It will consist of discussion sessions in which students will present assigned manuscripts followed by a general discussion of the topic directed by the instructor.  The course will cover the mechanisms of genome editing using host DNA repair systems, the function of Cas9, and how Cas9 can be harnessed to introduce defined mutations into almost any genome.  The use of Cas9 to activate or repress genes, alter chromatin modifications, and the application of these Cas9 systems to conducting genome-scale screens in mammalian cells as well as its use in studying cell fate will be highlighted.  Finally, we will study how Cas9 methodologies can be used to introduce disease-associated variants into pluripotent stem cells (e.g. iPSCs) that can be differentiated into disease-relevant cell for use in functional genomic studies.  1 unit.

L41 (BIO) 5512 Diseases of Membrane Transport & Excitability
Instructor: Robert Mercer, PhD, 362-6924
Classes will consider the molecular basis of the disease as well as animal models and current clinical studies. Addressing studies from the level of basic biophysical and molecular properties of the underlying ion channels/transporters, to the cellular defects, to organ and animal outcomes and therapies, which will encourage and force students to develop their ability to integrate understanding at multiple levels. Students will be introduced to emerging ideas in clinical diagnosis, management and treatment, when appropriate, clinical specialists will allow student participants to directly observe and participate in the clinical experience. Prerequisites: Bio 5068 Fundamentals of Molecular Cell Biology. Credit: 2 units.

L41 (BIO) 554 NEURAL SCIENCES
For full description, see the Department of Anatomy and Neurobiology, M35 554 Neural Sciences.

L41 (BIO) 5565 ORAL PRESENTATION OF SCIENTIFIC DATA
Instructor: Staff, Neurosciences Program, 362-7189
Practical course on how to prepare and present scientific data to an audience. Prerequisite: first-year neuroscience program courses. Meets once a week for 90 minutes. Credit: 1 unit.

L41 (BIO) 5571 CELLULAR NEUROBIOLOGY
Instructor: Paul Taghert, PhD, 362-3641
This course will present a fully integrated overview of nerve cell structure, function and development at the molecular and cellular level. Broad topics to be covered include gene structure and regulation in the nervous system, quantitative analysis of voltage- and chemically-gated ion channels, presynaptic and postsynaptic mechanisms of chemical neurotransmission, sensory transduction, neurogenesis and migration, axon guidance and synapse formation. Two lectures plus one hour of discussion per week for 14 weeks. There will be three exams, as well as homework problems and summaries of discussion papers. Prerequisite: graduate standing or permission of the instructor. Credit: 4 units.

L41 (BIO) 5619 ADVANCED COGNITIVE, COMPUTATIONAL AND SYSTEMS NEUROSCIENCE
Instructor: Todd Braver, PhD, 935-5143
This course will develop critical thinking and analysis skills with regard to topics in Cognitive, Computational and Systems Neuroscience. Course format will be a series of modules composed of intensive, faculty-led case studies on interdisciplinary topics at the intersection of psychology, computation and neuroscience. The goal will be to highlight the benefits of integrative, interdisciplinary approaches, by delving into a small set of topics from a variety of perspectives, rather than providing a survey-level introduction to a broader set of topic areas. Modules will involve a combination of lectures and student-led discussion groups, with students further expected to complete a multidisciplinary integrative final review paper. Case-study topics will vary somewhat from year to year, but are likely to include some of the following: temporal coding as a mechanism for information processing, coordinate transformations in sensory-motor integration, mechanisms of cognitive control, motor control strategies including application to neural prosthetics, and memory systems in health and disease. Credit: 3 units. Same as L33 Psych 519.

L41 (BIO) 5622 COGNITIVE, COMPUTATIONAL AND SYSTEMS NEUROSCIENCE PROJECT BUILDING
Instructor: Deanne M. Barch, PhD, 935-8729
The goal of this course is to help students in the CCSN Pathway develop the critical thinking skills necessary to develop and implement high-quality, interdisciplinary research projects. Throughout the course of the semester, students will develop a research plan in their chosen area of interest. The plan will be developed in consultation with at least two faculty members (from at least two different subdisciplines within the pathway) as well as the other students and faculty participating in the course. The culmination of this course will be for each student to produce an NIH-style grant proposal on the research project of their choosing. For most students, this will serve either as their thesis proposal or a solid precursor to the thesis proposal. The course will be designed to help facilitate the development of such a research plan through didactic work, class presentations, class discussion, and constructive feedback on written work. The course will begin with a review of written examples of outstanding research proposals, primarily in the form of grant submissions similar to those that the students are expected to develop (i.e., NRSA style proposals, R03 proposals). Review of these proposals will serve as a stimulus to promote discussion about the critical elements of good research proposals and designs in different areas. Each student will be expected to give three presentations throughout the semester that will provide opportunities to receive constructive feedback on the development and implementation of research aims. The first presentation (toward the beginning of the semester) will involve presentation of the student’s general topic of interest and preliminary formulation of research questions. Feedback will emphasize ways to focus and develop the research hypotheses into well-formulated questions and experiments. The second presentation will involve a more detailed presentation of specific research questions (along the lines of NIH-style Specific Aims) and an initial outline of research methods. The final presentation will involve a fuller presentation of research questions and proposed methods. Feedback, didactic work and group discussion throughout the semester will include guidance on critical components of the development of a research plan, including how to perform literature searches, formulate testable hypotheses, write critical literature summaries and design experiments and analyses. The course will meet once a week, with faculty members from different tracks within the pathway present at each meeting. This will allow students to receive feedback from several perspectives. Prerequisite: Member of CCSN Pathway, permission of instructor. Credit: 3 units. Same as L33 Psych 5191.

L41 (BIO) 5646 NEUROSCIENCES PROGRAM 1ST YEAR FUNDAMENTALS
Instructors: Paul Shaw, PhD, 362-2703; Lawrence Snyder, MD, PhD, 747-3530; John Pruett, MD, PhD, 747-6751
This course will provide a two-part introduction to Neuroscience Research fundamentals. Namely, it will introduce elementary statistical analysis for Neuroscience research and an introduction for grant-writing to support Neuroscience-related research. Prereq, limited to first year neuroscience students. Credit: 0.5 units.

L41 (BIO) 5651 NEURAL SYSTEMS
Instructor: Lawrence Snyder, MD, PhD, 747-3530
The course will consist of lectures and discussions of the sensory, motor and integrative systems of the brain and spinal cord, together with a weekly lab. The lectures will present aspects of most neural systems and will be given by faculty members who have specific expertise on each topic. The discussions will include faculty-led group discussions and papers presented and discussed by students. The labs will include human brain dissections, examination of histological slides, physiological recordings, behavioral methods, computational modeling and functional neural imaging. Credit: 6 units.

L41 (BIO) 5657 BIOLOGICAL NEURAL COMPUTATION
Instructor: Baranidharan Raman, PhD , 935-8538
This course will consider the computations performed by the biological nervous system with a particular focus on neural circuits and population-level encoding/decoding. Topics include, Hodgkin-Huxley equations, phase-plane analysis, reduction of Hodgkin-Huxley equations, models of neural circuits, plasticity and learning, and pattern recognition & machine learning algorithms for analyzing neural data. Note: Graduate students in psychology or neuroscience who are in the Cognitive, Computational, and Systems Neuroscience curriculum pathway may register in L41 5657 for three credits. For non-BME majors, conceptual understanding, and selection/application of right neural data analysis technique will be stressed. Hence homework assignments/examinations for the two sections will be different, however all students are required to participate in a semester long independent project as part of the course. Calculus, Differential Equations, Basic Probability and Linear Algebra. Undergraduates need permission of the instructor.     Prerequisites: Permission from the instructor. Credit: 3 units. Same as E62 BME 572.

L41 (BIO) 5663 NEUROBIOLOGY OF DISEASE
Instructor: Conrad Weihl, MD, PhD, 362-6981
This is an advanced graduate course on the pathology of nervous system disorders. This course is primarily intended to acquaint Neuroscience graduate students with a spectrum of neurological diseases, and to consider how advanced neuroscientific approaches may be applied to promoting recovery in the brain. Topics will be presented by Washington University faculty members and include: neurooncology, stroke, retinal disease, perinatal brain injury, neurodegenerative disorders, neuroinflammation, epilepsy, and psychiatric disorders. The class will meet for 2 hours each week. Each session will be led by a faculty guest with expertise in a specific neurological or psychiatric disease. In the first hour, the speaker will discuss clinical manifestations and pathophysiology. Where possible, the clinical presentation will be supplemented with a patient demonstration or videotape. After a 30-minute break for pizza and soda, the second hour will follow a journal club format. Two or three students will review current papers assigned by the speaker or course director. This course is offered in alternate years. Prereq: Introductory neuroscience course at the graduate or medical school level.  Credit: 2 units.

L41 (BIO) 5678 CLOCKSCLUB
Instructors: Erik Herzog, PhD, 935-8635; Paul Taghert, PhD, 362-3641
Clocksclub focuses on recent advances in the study of biological timing including sleep and circadian rhythms. Participants discuss new publications and data on the molecules, cells and circuits underlying daily rhythms and their synchronization to the local environment. Students registered for this journal club will lead a discussion once during the semester. Prereqs: BIO 2970 or permission of instructor. Credit: 1 unit.

L41 (BIO 5702 CURRENT APPROACHES IN PLANT RESEARCH
Instructor: Plant Biology Program; 362-3364
This course is designed to introduce graduate students to contemporary approaches and paradigms in plant biology. The course includes lectures, in-class discussions of primary literature and hands-on exploration of computational genomic and phylogenetic tools. Evaluations include short papers, quizzes, and oral presentations. Over the semester, each student works on conceptualizing and writing a short NIH-format research proposal. Particular emphasis is given to the articulation of specific aims and the design of experiments. Students provide feedback to their classmates on their oral presentations and on their specific aims in a review panel. Prereq: Bio 5703 or permission of the instructor. Credit: 4 units.

L41 (BIO) 5703 EXPERIMENTAL DESIGN AND ANALYSIS IN BIOLOGICAL RESEARCH
Instructor: Plant Biology Program ; 362-3364
In-depth exploration of landmark and current papers in genetics, molecular and cell biology, with an emphasis on prokaryotes and eukaryotic microbes. Class discussions will center on such key discoveries as the chemical nature of genetic material, the genetic code, oxygen producing light-spectrum, cell-cell signaling, transcriptional regulation, the random nature of mutation, and cell cycle regulation. Emphasis will be placed on what makes a good question or hypothesis, expedient ways to address scientific problems, and creative thinking. The last third of the course will consist of student-run seminars on selected topics to increase proficiency in the synthesis of new material and public presentation skills. Credit: 2 units.

L41 (BIO) 5723 SEMINAR IN PLANT AND MICROBIAL BIOSCIENCE
Instructor: Staff, Plant Biology Program, 362-3364
This course emphasizing presentation skill and critical analysis counts towards the PMB Graduate Program’s journal club course requirement. Students will be responsible for dividing and presenting 30 current research publications selected by the course masters. In addition to assembling brief PowerPoint presentations providing background and significance for their assigned articles,  students are expected to provide classmates with a 1 page primer and short list of relevant references  2 units.

L41 (BIO) 580 SEMINAR IN POPULATION BIOLOGY
Instructor: Staff, Evolution, Ecology and Population Biology, 362-3364
This weekly seminar, covering different topics each semester, should be taken by graduate students in the program. Prerequisite: graduate standing or permission of the instructors. Credit: variable; 2 or 3 units.

L41 (BIO) 582 ETHNOBIOLOGY JOURNAL CLUB
Instructors: Gayle Fritz, PhD, 935-8588; Jan Slick, PhD, 577-5165
Students in this journal club will meet weekly with ethnobotanists, ethnozoologists and ecologists from various St. Louis institutions (including Washington University, University of Missouri-St. Louis, Saint Louis University and the Missouri Botanical Garden) to discuss recent publications and ongoing research. Enrolled students will attend the journal club every week, and once per semester will choose a paper and lead the discussion. Credit: 1 unit. Same as home course L48 Anthro 560.

L41 (BIO) 585 SEMINAR IN FLORISTIC TAXONOMY
Instructor: Peter Hoch, PhD, 577-5175
This weekly seminar provides an introduction to/overview of Plants, each semester progressively covering orders and families in a sequence derived from the Angiosperm Phylogeny Website (http://www.mobot.org/MOBOT/Research/APweb/welcome.html); in Spring 2014, the seminar will finish the monocots and begin the eudicots. Weekly presentations include a summary of all relevant information (molecular, chemical, anatomical, embryological, morphological, ecological, geographical, historical/paleontological, etc.) about the plant group under consideration, review of the classification/phylogeny of the group, examination of fresh and/or preserved specimens, and discussion of relationships, human uses, and other relevant aspects of the biology of that group. Credit will be contingent on one (or two) seminar presentation(s) per student, regular attendance and active participation in group discussions. Credit: 1 unit.

L41 (BIO) 5862 SEMINAR ON PROFESSIONAL DEVELOPMENT FOR GRADUATE STUDENTS IN ECOLOGY, EVOLUTION & POPULATION BIOLOGY
Instructor: Eleanor Pardini, PhD, 935-4884
This is a weekly discussion seminar course in which advanced graduate students and postdocs in STEM will discuss the practices of scientific teaching and basic professional development skills. Topics covered will include scientific teaching, active learning, assessment driven instruction, creation inclusive classrooms, preparing for job interviews, preparing grant proposals, and balancing family and work. There will be several panel discussions with invited speakers on a range of potential career options to STEM PhDs. Students will prepare or revise their professional portfolio materials over the course of the semester. The course is open to all DBBS graduate students and is required for GAANN fellows. Prereq: Graduate student status in the DBBS or permission of instructor. Credit: 1 unit.

L41 (BIO) 590 RESEARCH
Instructors: Staff, Division of Biology and Biomedical Sciences, 362-3365
Credit to be arranged. Research is listed as 900-level course in each department.

L41 (BIO) 5902 INTRO TO THE SCHOLARSHIP OF TEACHING AND LEARNING
Instructor: Denise Leonard, 935-6142;
In this course, students will be introduced to the fundamentals of the Scholarship of Teaching and Learning (SoTL), including the practice of developing, reflecting on, and evaluating teaching methods to improve student learning. The scholarship of teaching and learning incorporates knowledge from educational and cognitive-psychology research, and it leads to the dissemination of new knowledge to a broad audience of educators. Students will learn to articulate questions about classroom teaching that can be addressed in a SoTL research project. Working from these questions, students will develop research hypotheses; design an evaluative plan; describe specific research methods (including the type of data to be collected); write an IRB application; understand how to analyze the data relative to the hypotheses. By the end of this course, students will have designed a research plan for a SoTL project. Same as U29 Bio 4902. Credit: 1 unit.  Same as U29 Bio 4902.

L41 (BIO) 5911 SEMINAR IN BIOLOGY AND BIOMEDICAL SCIENCES
Instructors: Staff, Division of Biology and Biomedical Sciences, 362-3365
These seminars cover the recent literature in various areas not included in other courses, or in more depth than other courses. Credit to be arranged.

L41 (BIO) 5913 BIOLOGICAL SYSTEMS ENGINEERING
Instructor: Kristen Naegle, PhD, 935-7665
This project-based (MATLAB) class will introduce several current techniques for systems-level measurement of molecules and a set of computational techniques for inferring biological meaning from such experiments. Several molecular types and measurement techniques will be covered. How to determine the quality of measurements will lay the groundwork for understanding a new measurement technique. From there, computational topics will include dimensionality reduction techniques, correlations between measurements and outcomes, and network modeling and inference. A working knowledge of molecular biology, differential equations, linear algebra, and statistics is required. Credits: 3 units.

L41 (BIO) 5915 TEACHING PRACTICE IN BIOLOGY AND BIOMEDICAL SCIENCES
Instructor: John H. Russell, PhD, 362-2558
Students serve as teaching assistants for undergraduate and graduate-level courses. Faculty-supervised activities include lecture preparation and presentation, leading discussion and problem-solving sessions and laboratory instruction. Prerequisite: restricted to graduate students in the Division of Biology and Biomedical Sciences. Credit: 1 unit.

L41 (BIO) 5922 ENTERING MENTORING
Instructor: Kathryn Miller, PhD, 935-7305
This course is a series of facilitated discussions aimed at developing and improving mentoring skills for those involved in supervising undergraduate research experiences. It is designed for postdocs and graduate students who are or will be ´bench mentors´ for undergraduates doing Bio 500 and/or Summer Research. Participants will receive “Entering Mentoring” materials, including articles and worksheets to facilitate mentoring interactions with their mentee, plus several resource books relevant to mentoring. They will develop a mentoring philosophy statement, work on specific assignments designed to improve their relationship with their mentee and share their present and past experiences as mentors and mentees. Bench mentors will be eligible for a travel award to help defray expenses for attending a meeting with their mentee, if that student wins one of the HHMI SURF travel awards (4-5 awarded annually) or is otherwise being supported to present at a scientific meeting.  Prereq: open to graduate students and postdocs, with priority for those who plan to mentor undergraduates in summer research experiences. Graduate students and postdocs do NOT need to be mentoring a student at the time of the course; it is open to all with an interest in mentoring now or in the future. Note: The sessions will be held either at the beginning of the day or the end of the day at the Danforth campus. Once registration closes, an email will be sent to those registered to poll for the best days & times. Credit: 1 unit. Same as U29 Bio 492.